When you're experiencing pain, fever, or inflammation, two of the most popular over-the-counter (OTC) medications come to mind: Tylenol and Advil. These household names are found in nearly every medicine cabinet in Canada, including Toronto, where Symington Drugs Pharmacy provides both options for pain and fever relief. However, many people often ask: What is the difference between Tylenol and Advil? Are Tylenol and Advil the same? Which is better for a fever, Tylenol or Advil? Or, more importantly, which is better for you — Tylenol or Advil?

In this comprehensive guide, we'll explore the Tylenol Advil difference in detail. From how each works, to which is stronger, safer, and better suited for specific conditions, we'll help you make an informed choice based on science and practical use.
Tylenol vs Advil: A Quick Comparison
Before diving deeper, here’s a quick side-by-side comparison to understand the fundamental difference between Advil and Tylenol:
Aspect | Tylenol | Advil |
---|---|---|
Generic Name | Acetaminophen | Ibuprofen |
Drug Class | Analgesic / Antipyretic | NSAID (Nonsteroidal Anti-Inflammatory Drug) |
Primary Uses | Pain relief, fever | Pain relief, fever, inflammation |
Anti-Inflammatory? | No | Yes |
Common Side Effects | Liver toxicity (overuse) | Stomach irritation, ulcers, kidney issues |
Mechanism of Action
Is Advil the same as Tylenol? Absolutely not. These drugs differ in how they affect the body:
- Tylenol (acetaminophen) works primarily in the brain to block pain signals and regulate body temperature.
- Advil (ibuprofen) works both centrally and peripherally by inhibiting cyclooxygenase (COX) enzymes, reducing inflammation at the site of pain or injury.
Which is Stronger: Tylenol or Advil?
What is stronger, Advil or Tylenol? The answer depends on the type of discomfort you're addressing:
- For inflammatory pain (e.g., arthritis, sprains), Advil is generally more effective.
- For headaches, dental pain, or fever, Tylenol and Advil can be equally effective.

This difference is due to Advil’s anti-inflammatory properties, something Tylenol lacks. So, if you're comparing Tylenol vs Advil for swelling, Advil is typically the better choice.
Fever Reduction: Tylenol or Advil?
Many parents and adults wonder: Which is better for a fever, Tylenol or Advil? Clinical studies show that both reduce fever effectively. In some cases, alternating between the two (under medical guidance) may offer superior fever control.
You can browse our Pain & Fever Relief Products at Symington Drugs Pharmacy, including various formulations of Tylenol and Advil for adults and children.
Side Effects and Safety Profiles
Which is safer, Tylenol or Advil? Again, it depends on the individual’s health profile:
Tylenol Safety
- Safe for most people when used as directed
- Can cause liver damage in high doses or when mixed with alcohol
Advil Safety
- Effective for pain and inflammation
- Can irritate the stomach lining, raise blood pressure, and affect kidney function if overused
Who Should Avoid Tylenol or Advil?
- Avoid Tylenol: if you have liver disease or consume alcohol regularly.
- Avoid Advil: if you have ulcers, heart conditions, kidney disease, or are taking blood thinners.
Are Tylenol and Advil the Same?
Is Advil and Tylenol the same? No, they are chemically and functionally different. Though both are used for pain relief and fever, their properties and risks are not identical.
Can You Take Tylenol and Advil Together?
Yes, you can alternate them under a healthcare provider’s guidance. This can be helpful for managing high fevers or severe pain, especially in post-operative care or pediatric treatment.
Some studies have shown that alternating Tylenol and Advil every 3 hours provides better pain and fever control than using either one alone. But make sure you’re not doubling doses by mistake.

Compare Tylenol and Advil by Condition
Condition | Recommended Option | Notes |
---|---|---|
Fever | Tylenol or Advil | Both effective |
Inflammation | Advil | NSAID benefit |
Headache | Either | Depends on tolerance |
Back Pain | Advil | Anti-inflammatory effect |
Pregnancy | Tylenol | Advil usually not recommended |
Stomach Ulcers | Tylenol | Gentler on stomach |
Product Availability at Symington Drugs Pharmacy
Looking to relieve pain or bring down a fever? We stock both Advil and Tylenol in various forms:
- Regular Strength Tylenol Tablets
- Extra Strength Tylenol Caplets
- Children’s Tylenol Liquid
- Advil Liqui-Gels
- Children’s Advil Suspension

Shop pain and fever relief products now »
Frequently Asked Questions (FAQs)
Is Tylenol better than Advil?
Not necessarily. Tylenol is preferred for people with stomach sensitivity, while Advil is better for inflammation.
Which is better: Tylenol or Advil?
Depends on your symptoms. Use Tylenol for general pain or fever. Use Advil for pain with swelling or inflammation.
Is Tylenol or Advil better for inflammation?
Advil, as Tylenol lacks anti-inflammatory properties.
Is Tylenol or Advil better for a fever?
Both are effective. Choose based on tolerance or alternate under guidance.
Which is better for you, Tylenol or Advil?
For people with liver issues, choose Advil. For those with kidney or GI issues, Tylenol is better.
Conclusion
The difference between Tylenol and Advil is clear: though they treat many of the same symptoms, they do so via different mechanisms and come with distinct risks. So when asking, "Is Advil like Tylenol?" or "Is Advil the same as Tylenol?", the answer is no.
Whether you're looking for the best for fever: Tylenol or Advil, or wondering which is better for inflammation: Tylenol or Advil, your decision should be based on your health profile, symptoms, and physician’s advice.
Trusted References
- Drugs.com https://www.drugs.com/medical-answers/tylenol-advil-difference-3126965/
- MercyCare.org https://www.mercycare.org/healthy-living/health-education/tylenol--advil--when-to-use-which/
- GoodRx https://www.goodrx.com/ibuprofen/advil-vs-tylenol
- HSS.edu https://www.hss.edu/article_difference-between-tylenol-advil-aleve.asp
- OSF Healthcare https://www.osfhealthcare.org/blog/acetaminophen-vs-ibuprofen-which-should-you-pick/
For all your OTC medication needs, including Advil Tylenol products, visit Symington Drugs Pharmacy online.